Release date: 2012-11-14
A team led by Professor Okano, a professor at Keio University in Japan, recently discovered that a compound can promote the regeneration of corneal sensory nerves that have been severed.
The cornea is rich in sensory nerves, but in myopia correction, corneal transplantation and other operations, the sensory nerves may be cut off, infection may also damage the nerves and damage the patient's vision. It usually takes a few months to a year or two to sense nerve regeneration, and promoting nerve regeneration can improve symptoms.
The team noted that a protein called sema3A (sema3A) would inhibit nerve growth. They extracted SM-345431, a compound that inhibits the function of this protein, from the mold of the soil, and injected it into the experimental mice that transplanted the cornea.
About 3 weeks later, the researchers found that the sensory nerves of the cornea had regenerated, but the rats in the control group did not.
At present, researchers are using the induction of pluripotent stem cells (iPS cells) to achieve corneal regeneration, and in order to make the transplanted cornea function, it is necessary to regenerate the nerve. Okano and others in the new issue of the "Science Public Library - Comprehensive" report research group pointed out: "This compound may be used as a therapeutic drug in the future to improve the success rate of corneal transplantation, thus contributing to the postoperative management of corneal surgery. ."
Source: Kexun
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