How do common diseases happen?
September 02, 2016 Source: Bio Valley
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Recently, researchers from the University of Auckland have clarified the causes of common diseases such as diabetes, cancer and dementia. The research is published in the international journal Mitochondrion , which is to clarify the process of mitochondria in human development and disease. The important role provided a certain help.
Mitochondria are special subunits in cells, and they are also energy plants in cells. Mutations in mitochondrial DNA are common, and this is also associated with common diseases and the development of a series of fatal progressive diseases, such as diabetes, gastrointestinal disorders, Heart disease, dementia, deafness and eye disorders. In this study, researchers first discovered that DNA in human mitochondria can leave the mitochondria, enter the nucleus and interact with many genes.
Researcher Justin O'Sullivan said that we found that mitochondrial DNA can "talk" to the DNA of the nucleus, and the interaction between the two is not random. These findings virtually expand our understanding of mitochondria. That is, mitochondria may not only provide energy, but also regulate the function of cell metabolism. Researchers believe that these connections may be a feedback system between the mitochondria and the nucleus, and that the feedback system may affect the growth and development of the human body, and we all know that the link between the two affects the yeast cell nuclear gene. Work, so the researchers speculate whether this effect will also exist in the human body?
The interaction of DNA in mitochondria and nucleus may be an important way to influence the expression of genes in the environment. There is a theory that mitochondrial disease is that the damaged mitochondria cannot function as a cell, so it does not play a normal role, but this study may have found Another "culprit" is the "dialogue" between mitochondria and the nucleus; mitochondrial abnormalities are often directly related to highly prevalent diseases such as obesity, diabetes and cancer, and this study may increase the understanding of researchers. That is, as long as the way to change the mitochondria may indicate the occurrence of the disease, of course, later researchers will conduct in-depth research to explore the mystery.
In the next step, the researchers will clarify the molecular mechanism of "conversation" of DNA in mitochondria and nucleus through more research, and how it triggers related effects, which can lead to disease.
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