The core technology of bioartificial liver is functional hepatocytes for treatment. At present, bioartificial liver developed at home and abroad mainly uses porcine primary hepatocytes or human hepatoma cells as a source of functional hepatocytes. However, these cells have large defects in safety or in terms of functionality, which seriously depresses the clinical application of bioartificial liver. Therefore, obtaining new functional liver cells is a key step in promoting the clinical application of bioartificial liver.
In this study, scientists filled "hiHep cells" into bioartificial liver and observed their treatment of pigs with acute liver failure. The experimental results show that untreated acute liver failure pigs generally die in about 3 days, while the survival rate of acute liver failure pigs treated with "hiHep cells" bioartificial liver is 80%. After survival, the pig's indicators gradually returned to normal levels.
According to researcher Hui Lijian, the liver is similar to a "chemical plant", which itself has the functions of biosynthesis and metabolic detoxification. If the liver cells have been depleted, in the case of almost loss of these functions, the doctor can participate in the normal liver function activities of the human body by means of some foreign liver cells, which can help the patient to go through an extremely difficult and dangerous period. This study demonstrates for the first time that the bio-artificial liver system based on “hiHep cells†is effective and safe in large animal treatment experiments, which provides a solid foundation for further clinical research in the next step.
At present, China has become the world's largest social cost for hepatitis B, cirrhosis and liver cancer. Experts predict that the research results of the new bioartificial liver system are expected to significantly improve the survival time of patients, and strive for more rescue time for liver treatment and liver replacement.
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