For example, women suffering from tuberculosis, due to taking rifampicin, will accelerate the metabolism of estrogen and progesterone, and their concentration in the blood will be significantly reduced, which will affect the contraceptive effect. Another example is epilepsy patients taking peptone, ethosuximide, phenytoin sodium, phenobarbital and carbamazepine drugs, can promote the increase of drug metabolism enzymes, thereby accelerating the destruction of oral contraceptives, at the same time, will increase the number of pregnant The combination of hormones and globulin, so that the concentration of free drugs greatly reduced, which will lead to contraceptive failure.
Again, when patients use tetracycline, erythromycin, chloramphenicol, ampicillin and nitrofurantoin, and compound sulfamethoxazole, their relatives will increase the rate of pregnancy in women. Because when the body absorbs estrogen, about 60% of the glucuronic acid conjugates are excreted in the gall bladder. As the bacteria pass through the intestinal tract, the conjugates are hydrolyzed and the estrogens are released and absorbed by the body. . However, the use of the above antibiotics inhibited the growth and reproduction of bacteria in the intestine, and prevented the reabsorption of estrogen, so contraception would also fail. There are tranquility, clotrimazole, griseofulvin, hydrocortisone, etc., which will affect the role of oral contraceptives.
Conversely, oral contraceptives also have a greater impact on some of the drugs that are used in combination, or they lead to reduced efficacy or toxic side effects, so they cannot be ignored. For example, oral contraceptives can delay the metabolism of corticosteroids (especially hydrocortisone), increase the therapeutic effect, and increase side effects. Another example is the use of oral contraceptives to promote the blood pressure drug reserpine, methyldopa, etc. have the effect of enhancing the stimulation of the secretion of prolactin, causing breast hyperplasia and galactorrhea. Antipsychotics such as chlorpromazine and imipramine also have similar conditions. In addition, oral contraceptives can also increase the risk of adverse cardiovascular reactions to smoking, and this risk increases with age and smoking, especially for women over the age of 35 are quite common, it should be a non-smoking.
In short, women taking oral contraceptives should pay attention to the choice of drugs when they use drugs, or switch to other contraceptive measures to prevent drug interactions.
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