Bupleurum tenue Buch. -Ham., alias Jin Chaihu (Leibo County, Liangshan, Sichuan), Weichaihu (Ganluo County, Huidong County, Sichuan Province), Bamboo Leaf Bupleurum (Nanchuan County, Sichuan Province), Silver Bupleurum (Yunnan).
Efficacy and effect directly kill tumor cells In recent years, studies have found that the anti-cancer mechanism of Xiaochaihu Decoction mainly includes: directly killing tumor cells and regulating immune function. Inhibits tumor cell growth. The direct killing effect of Xiaochaihutang is manifested by inducing tumor cell apoptosis in addition to significantly inhibiting tumor growth and metastasis. Yang Huiling of Zhongshan Medical University found through in vivo experiments. 4. Tang extract has obvious inhibitory effect on Stso cells in tumor-bearing mice. The tumor inhibition rate was 40.19%~58.7%. At the same time, the apoptosis characteristics of Slso cells were observed. It is characterized by small cell volume, nuclear pyknosis, cytoplasmic and nuclear chromatin agglutination. The density is increased, and there are a large number of apoptotic bodies between cells.
Endothelin (ED is an active polypeptide synthesized by vascular endothelial cells, etc., Zui recently found that it can be used as a growth factor to stimulate the abnormal proliferation of cells through paracrine and autocrine effects, which is related to the occurrence and development of tumors. Yang Huiling et al. In vivo experiments were carried out to observe the inhibitory effects of different concentrations of soup extract on mouse sarcoma Slso, and the changes of plasma ET content in tumor-bearing mice were determined by radioimmunoassay fRIAl. It was found that different concentrations of soup extracts were obvious to mouse sarcoma. Inhibition. At the same time, it was found that the plasma ET level of the mice decreased significantly after treatment, reaching normal or lower than normal levels, suggesting that its mechanism may be related to lowering plasma ET levels in tumor-bearing mice.
Modern studies have shown that there are three stages in the development of cancer in a chemical carcinogenic model: the stage of DNA damage by reactive oxygen species is the initial stage: the stage of increased DNA damage-stage; the stage of increasing cancer cells. Japanese scholar Shi Tiangang passed the determination of 8-hydroxy-deoxyguanosine (8 OHdG) levels in mice. Clarified the new mechanism of soup inhibition of carcinogenesis: soup 0.1 mg / ml. It can eliminate about 20% of active oxygen; the clearance rate is about 30% at 0.3 mg/ml; the clearance rate at 1.0 mg/ml is about 70%. That is, the soup can remove reactive oxygen species in a dose-dependent manner, which has an inhibitory effect on the initial stage of canceration.
Regulating immunosuppressive cancer The soup activates macrophages. Regulate the body's immune function. Domestic scholars used the method of measuring the phagocytosis of mouse peritoneal macrophages to observe the effect of Chinese medicine soup on the immune function of mice. The experimental results showed that 4, 8 and 46 hours after the soup was given. The phagocytic rate and phagocytic index of the peritoneal macrophages of the experimental mice were increased to different extents, and the Zui was significantly increased in the 16-hour group. on the other hand. Studies have found that soup can affect lymphocytes to regulate immune function. Some people used T cell colonies as indicators to find that the soup has an enhanced effect on T cell colony formation. Later, it was found that the effect was not mainly Bupleurum, but mainly ginseng, ginger and part of Pinellia ternata. .
In addition, with the deepening of cytokine research, people found. The soup may play a role in regulating immunity by affecting the expression of cytokines. Soup can activate macrophages. Promote the production of interleukin-1 (IL-1) and interleukin-2 (IL-2). Enhance the sensitivity of interleukin-3 (IL-3): interleukin-4 (IL-4) produced by monocytes in the peripheral blood of human body and interleukin (IL-6) produced by splenocytes Enhance its role. Domestic scholars have shown that a small dose of soup (100 mg / kg) can increase the activity of natural killer cells (NK) in mice, and large doses can inhibit the activity of NK (200 mg / dry gram). Moreover, oral soup can significantly inhibit and delay the growth and development of Ehrlich ascites tumors, and can produce low-cost tumor necrosis factor (TND. The soup induces the production of TNF. It is the result of activation of the reticuloendothelial system.
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