Release date: 2014-05-23
In reality, why do some people have higher tolerance for pain than others? Not long ago, the American Academy of Neurology gave the answer at the annual meeting in Philadelphia, Pennsylvania: it is genetics in the "work".
Unlike acute pain, chronic pain is persistent, and pain signals can continue to excite in the nervous system for weeks, months, or years.
Often the patient's chronic pain may be due to persistent illnesses such as arthritis, cancer or infections; or from one-time injuries such as sprains in the back; it can even occur in people who have not suffered from injuries or illnesses.
At present, doctors can take a variety of methods in the treatment of chronic pain, such as drugs, acupuncture, local electrical stimulation, brain stimulation, and may even use surgery. Of course, there are also cases where doctors use placebo to treat patients with chronic pain.
In combination with previous studies, researchers have found that there is often a low level of endorphin in the spinal fluid of patients with chronic pain, so the ultimate goal of some treatments is to stimulate endorphin levels.
In this new research project, the researchers asked a total of 2,721 patients with chronic pain, and the pain intensity score was 0 to 10, and all patients were taking opioid analgesics.
The researchers first divided the participants into three groups. Patients with a pain score of 1 to 3 were classified as "low pain", 4 to 6 were "middle pain", and "high pain" was defined as 7 to 10 points.
The final score statistics showed that most of the patients (46%) had a moderate pain, followed by a high pain (45%). Only 9% of participants had low pain and patients with any pain score of 0 were abolished.
Later, after rigorous and meticulous experiments, the researchers found that the distribution of the genetic variant DRD1 in the low-pain group was 33% higher than that in the high-pain group. The middle pain group was more likely to have two other variants, COMT and OPRK, which were 25% and 19% higher, respectively, than the high pain group. At the same time, the high pain group was more likely to be DRD2 and 25% higher than the middle pain group.
“This study provides an objective way to understand the causes of pain and different degrees of pain tolerance in different individuals.†Research author Dr. Tobore Onojjighofia said that examining a person with these four genes would better help doctors understand The patient's sensitivity to pain.
Finding these genes that may have an effect on pain perception, in Dr. Onojjighofia's view, is most important to provide goals for new treatments.
Subsequently, this study, combined with clinical work, confirmed that antibodies can cure 40% of patients with chronic pain. Neurofrozen may also be an effective treatment. In addition, another study suggests that fish oil supplements can also be used as a more natural alternative to chronic pain.
Source: Chinese Journal of Science
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