The molecular machine that started the process of splitting biological cells into two identical daughter cells seems to have been working hard in the early stages of evolution. This molecular machine has been preserved for generations in three types of life on earth.
Researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory and the University of California, Berkeley, have confirmed that the core machines that initiate DNA replication are the same in the three life worlds -- archaea, bacteria, and eukaryotes.
In two papers to be published in the August Nature Structural and Molecular Biology, researchers announced that a helix base structure of the AAA+ protein superfamily was identified as DNA replication in bacteria, E. coli, and eukaryotic fruit flies. The "founder" of the molecule. Previous studies have determined that AAA+ protein is the core of DNA replication initiated by archaea. These new discoveries show that DNA replication is an ancient event that happened millions of years ago, before the differentiation between archaea, bacteria, and eukaryotes.
The ability of cells to replicate DNA in a timely and faithful manner is the basis for the survival of cells, but despite the fact that humans have been studying for decades, the mechanisms and molecular basis for initiating DNA replication and the degree to which these mechanisms are conserved in evolution have been misdefined and led to widespread argue.
The newly published two articles have achieved a new level of understanding of DNA opening and replisome construction through the use of many physiological research techniques.
These findings confirm the evolutionary kinship of DNA initiation in three areas. This paper on Drosophila was titled: "Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex". Another paper on E. coli was titled: Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling.
Researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory and the University of California, Berkeley, have confirmed that the core machines that initiate DNA replication are the same in the three life worlds -- archaea, bacteria, and eukaryotes.
In two papers to be published in the August Nature Structural and Molecular Biology, researchers announced that a helix base structure of the AAA+ protein superfamily was identified as DNA replication in bacteria, E. coli, and eukaryotic fruit flies. The "founder" of the molecule. Previous studies have determined that AAA+ protein is the core of DNA replication initiated by archaea. These new discoveries show that DNA replication is an ancient event that happened millions of years ago, before the differentiation between archaea, bacteria, and eukaryotes.
The ability of cells to replicate DNA in a timely and faithful manner is the basis for the survival of cells, but despite the fact that humans have been studying for decades, the mechanisms and molecular basis for initiating DNA replication and the degree to which these mechanisms are conserved in evolution have been misdefined and led to widespread argue.
The newly published two articles have achieved a new level of understanding of DNA opening and replisome construction through the use of many physiological research techniques.
These findings confirm the evolutionary kinship of DNA initiation in three areas. This paper on Drosophila was titled: "Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex". Another paper on E. coli was titled: Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling.