Australian research finds new ways to change the shape of nano drug carriers

Australian research finds new ways to change the shape of nano drug carriers

November 07, 2017 Source: Xinhua News Agency

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Researchers at the University of New South Wales in Australia have developed a new method that can change the shape of nanomedicine carriers, which will help their anticancer drugs to be released into the tumor and improve the effectiveness of anticancer drugs. “This breakthrough means that we can make polymer vesicles that change shape with the environment, such as ovals or tubes, and wrap the drug in it.” Lead research author, University of New South Wales School of Chemistry, Pal Sorda Professor Song said.

 
The University of New South Wales, Australia, recently issued a press release saying that researchers at the school have developed a new method that can change the shape of nanomedicine carriers, which will help their anticancer drugs to be released into tumors and improve anticancer drugs. effect.

 
The polymer molecule can automatically form a spherical hollow structure polymer vesicle in solution, which is widely used as a drug carrier because of its stability and versatility, but in comparison, bacteria and viruses in nature are tubular. , rod-shaped, this non-spherical biological structure can enter the human body more easily. Since the polymer vesicles are difficult to form a non-spherical structure, this limits to some extent its ability to deliver drugs to a destination in the human body.

 
Australian researchers used cryo-freezing electron microscopy to observe structural changes in polymer molecules in solution. They found that by adding a perylene polymer to the surface of the polymer vesicle, the shape and size of the polymer vesicle can be adjusted by changing the amount of water in the solvent.
 

"The breakthrough means that we can make polymer vesicles with shapes that change with the environment, such as ovals or tubes, and wrap the drug," said lead research author Professor Paul Sordasson of the School of Chemistry at the University of New South Wales. Among them. Preliminary evidence suggests that nanomedicine carriers with more natural shapes and non-spherical shapes are more likely to enter tumor cells.

 
The research results were published in the latest online edition of the British journal Nature Communications.

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