According to reports, British scientists modified the genetic code of nematodes, for the first time, an amino acid that does not exist in nature (http://.com/brand/zs.asp?bigclassname=%E8%A5%BF%E8%8D% AF%E4%BA%A7%E5%93%81&smallclassname=%E6%B0%A8%E5%9F%BA%E9%85%B8) was added to the body. Scientists say that the latest technology allows biologists to manipulate the molecules of living organisms at the atomic level and create proteins that are not found in nature. Related research (http://.com/) was published in the Journal of the American Chemical Society.
DNA (DNA) fragments with genetic information are called genes, and genes make amino acids available for biological organisms (http://.com/brand/zs.asp?bigclassname=%E8%A5%BF%E8%8D %AF%E4%BA%A7%E5%93%81&smallclassname=%E6%B0%A8%E5%9F%BA%E9%85%B8) protein molecules were constructed. There are 4 bases in the DNA: A (adenine), T (thymine), C (cytosine), and G (guanine), which are combined every three bases (http://.com/databases/db_8_1 Html) A codon, the codon determines the amino acid (http://.com/brand/zs.asp?bigclassname=%E8%A5%BF%E8%8D%AF%E4%BA%A7%E5%93% Attributes of 81&smallclassname=%E6%B0%A8%E5%9F%BA%E9%85%B8). Living organisms use different combinations of 20 amino acids to build the tens of thousands of proteins needed to sustain life.
However, in the latest study (http://.com/), Sebastian Grace and Jason Chen of the Cambridge Molecular Biological Laboratory changed a Caenorhabditis elegans (about 1 mm in length). The genetic mechanism of the transparent body contains only 1000 cells, adding the 21st amino acid that does not exist in nature to its genome.
Previously, the scientists of Scripps Research (http://.com/) had written articles in the Proceedings of the National Academy of Sciences, describing how they rearranged the three bases of a codon so that the cell could use a code. As a directive, they added an amino acid that does not exist in nature, but they only used E. coli for experiments.
The latest research is the experiment that scientists successfully performed on animals. The results showed that the artificial protein produced in each cell of the nematode fine body contains a fluorescent dye that emits pink light under the irradiation of ultraviolet rays. If it fails, there will be no such phenomenon.
Although scientists have also said that this is only a "proof of principle" study. However, Jensen Chen believes that this technology "is expected to change the face of biology", after which scientists can monitor the entire process of protein design and manufacturing process, so that artificial amino acids have specific new properties. Mario Di Bono, who works in the laboratory for nematodes, said: "This method can be applied to many animals. Biologists can use new methods to introduce proteins that can be controlled by light into the organism."
Jensen Chen cautiously admitted that he was "very excited" about the latest research. Dibono compares it with the scientists' research on green fluorescent protein. In 2008, the American scientist Xia Cunxiu, Martin Chalfi, and Chinese chemist Qian Yongjian won the Nobel Prize in Chemistry for their discovery and research of the contribution of green fluorescent protein (GFP). This protein has now become the most important in the contemporary biological sciences. tool.
DNA (DNA) fragments with genetic information are called genes, and genes make amino acids available for biological organisms (http://.com/brand/zs.asp?bigclassname=%E8%A5%BF%E8%8D %AF%E4%BA%A7%E5%93%81&smallclassname=%E6%B0%A8%E5%9F%BA%E9%85%B8) protein molecules were constructed. There are 4 bases in the DNA: A (adenine), T (thymine), C (cytosine), and G (guanine), which are combined every three bases (http://.com/databases/db_8_1 Html) A codon, the codon determines the amino acid (http://.com/brand/zs.asp?bigclassname=%E8%A5%BF%E8%8D%AF%E4%BA%A7%E5%93% Attributes of 81&smallclassname=%E6%B0%A8%E5%9F%BA%E9%85%B8). Living organisms use different combinations of 20 amino acids to build the tens of thousands of proteins needed to sustain life.
However, in the latest study (http://.com/), Sebastian Grace and Jason Chen of the Cambridge Molecular Biological Laboratory changed a Caenorhabditis elegans (about 1 mm in length). The genetic mechanism of the transparent body contains only 1000 cells, adding the 21st amino acid that does not exist in nature to its genome.
Previously, the scientists of Scripps Research (http://.com/) had written articles in the Proceedings of the National Academy of Sciences, describing how they rearranged the three bases of a codon so that the cell could use a code. As a directive, they added an amino acid that does not exist in nature, but they only used E. coli for experiments.
The latest research is the experiment that scientists successfully performed on animals. The results showed that the artificial protein produced in each cell of the nematode fine body contains a fluorescent dye that emits pink light under the irradiation of ultraviolet rays. If it fails, there will be no such phenomenon.
Although scientists have also said that this is only a "proof of principle" study. However, Jensen Chen believes that this technology "is expected to change the face of biology", after which scientists can monitor the entire process of protein design and manufacturing process, so that artificial amino acids have specific new properties. Mario Di Bono, who works in the laboratory for nematodes, said: "This method can be applied to many animals. Biologists can use new methods to introduce proteins that can be controlled by light into the organism."
Jensen Chen cautiously admitted that he was "very excited" about the latest research. Dibono compares it with the scientists' research on green fluorescent protein. In 2008, the American scientist Xia Cunxiu, Martin Chalfi, and Chinese chemist Qian Yongjian won the Nobel Prize in Chemistry for their discovery and research of the contribution of green fluorescent protein (GFP). This protein has now become the most important in the contemporary biological sciences. tool.
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