Stem cell technology for functional regeneration of whole pulp tissue
August 30, 2018 Source: Science and Technology Daily
Window._bd_share_config={ "common":{ "bdSnsKey":{ },"bdText":"","bdMini":"2","bdMiniList":false,"bdPic":"","bdStyle":" 0","bdSize":"16"},"share":{ }};with(document)0[(getElementsByTagName('head')[0]||body).appendChild(createElement('script')) .src='http://bdimg.share.baidu.com/static/api/js/share.js?v=89860593.js?cdnversion='+~(-new Date()/36e5)];Science and Technology Daily, Xi'an, August 29 (Reporter Shi Junbin) The reporter learned from the demonstration of the Stomatological Hospital of the Air Force Military Medical University on the 29th that the research team led by Professor Jin Yan of the hospital established a cell aggregation based on stem cell self-assembly by simulating the principle of tooth development. Body technology, the use of deciduous deciduous stem cells successfully achieved functional regeneration of the whole pulp tissue, the development of the first international full-length pulp regeneration clinical research and its success, its academic results recently published in "Scientific Translational Medicine."
Dental regeneration is very difficult, and the difficulty is reflected in pulp regeneration and periodontal tissue regeneration. The recovery of pulp regeneration ranks first, focusing on how the implanted cells survive in the narrow root canal of nearly 2 cm in length, how to integrate with the implanted jaw tissue, and let the vascular nerves in the jaw grow into the teeth. The medullary cavity ensures long-term spontaneous survival of the pulp and restores the function of the teeth.
In the past 200 years, human dental pulp disease has been treated with "root canal treatment" in clinical treatment. That is, the dentist has manually removed the dental pulp cells in the medullary cavity and root canal by manual operation and filled with biological materials. Since there is no nutrient supply, although the teeth are retained after filling, they gradually become brittle and discolored, and at the same time they lose their feeling, especially when they bite hard objects.
Facing the world problem of pulp regeneration, the research team led by Professor Jin Yan of the Stomatological Hospital of the Air Force Military Medical University has been working hard for more than 20 years to obtain dental pulp stem cells from the deciduous teeth of patients. After in vitro culture, the stem cell aggregates will be formed. Into the pulp cavity required by the patient, the nerves of the teeth are regenerated, and the original function of the teeth is completely restored. Especially for young patients whose teeth are developing, the teeth can develop to a normal state.
At present, this technology has been used in nearly 50 clinical patients, all of which have been completely successful. After scientific research, the technology is the first successful development of the first full-length pulp regeneration in the world, subverting the standardized therapy of “root canal treatment†for more than 200 years of traditional dental diseases. It has important milestone significance for further treatment of teeth. Weekly disease and missing teeth laid a solid foundation.
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