With the acceleration of economic globalization and the rise of the natural trend, Chinese medicine has gradually been recognized and accepted by the world, and the modernization of Chinese medicine has become increasingly important. In the process of modernization of traditional Chinese medicine, the modernization of traditional Chinese medicine may become a breakthrough. As the main weapon of Chinese medicine treatment, the reform of traditional Chinese medicine decoction will bear the brunt.
The traditional Chinese medicine decoction piece refers to a certain size of the original drug slice which is made by the process of net selection, selection and processing of Chinese medicinal materials under the guidance of the theory of traditional Chinese medicine, without any solvent extraction, concentration, granulation and Other processes. The clinical use can show the strong vitality due to the appropriate flexibility, reduction and subtraction of the drugs and drugs in the prescriptions due to time, place and people. However, traditional Chinese medicine decoction pieces have some shortcomings, such as temporary decoction before use, inconvenient to use and carry; raw materials are of different origin, quality is not good; some pieces are thick and large, the effective rate of active ingredients is low, the medicine Low utilization rate, wasted resources; some medicinal materials have poor shape and odor. Therefore, traditional Chinese medicine decoction pieces cannot be widely accepted. Therefore, the ideal modern Chinese medicine decoction pieces should conform to the requirements of TCM theory, convenient compatibility, convenient taking, controllable quality, and reasonable price. The author intends to compare the main new decoction pieces on the market, such as formula granules, nano-medicine, ultra-micro-medicine, etc. from the above aspects. Talk about personal views on the reform of the decoction.
"Scientific Chinese Medicine" is not scientifically recognized by the industry management department and is widely promoted in the market. The new Chinese medicine is a single-flavored formula granule. The formula granule is also called scientific Chinese medicine and free Chinese medicine. Zui originated in Japan, Korea and other countries. Then passed to our country. It is prepared by processing the single-flavored medicinal materials according to the physical and chemical properties of the traditional Chinese medicine, and is selected by modern industrial extraction, concentration, drying and granulation. Although it is easy to use and easy to use, it extracts all the active ingredients of single-flavored Chinese medicine in the industry. It needs to be heated during the concentration and drying process. The unstable components in the medicine may be lost. On the other hand, the pharmacological action of traditional Chinese medicine is not a single herb. The accumulation of active ingredients also includes the changes in the content of the components caused by adsorption, precipitation, solubilization, and solubilization during the decoction process, as well as the new substances produced by hydrolysis, oxidation and reduction between the components. Therefore, whether the simple mixing of the single-flavored Chinese medicine ingredients after extraction is equivalent to the traditional boiling is not certain. Studies have shown that Shengmai Sanhe Decoction is more effective than myocardial ischemia, and the combination of some drugs has attenuated and synergistic effects. It is well known that aconitine in aconite is not obvious when it is used alone, and it is easy to cause ectopic rhythm. Dried ginger and licorice have no cardiotonic effect. Sini decoction composed of aconite has a significant cardiotonic effect and the ectopic rhythm effect is greatly reduced. The mixture of single-flavored drug extracts can not reduce its toxicity. Because of this, Zui, who advocated the formulation of granules in Japan, Korea, Taiwan, etc., now uses less single-flavored granules, and the compound granules extracted after decocting are the main ones. Formula granules also have shortcomings such as the influence of the addition of excipients on the taste, easy to regain moisture and agglomeration.
Nano-Chinese medicine is difficult to promote Nano-Chinese medicine refers to the active ingredients, effective parts, original medicines and their compound preparations of traditional Chinese medicine manufactured by using nanotechnology in the range of 100nm particle size. Nano-medicine decoction pieces are only a part of them. The molecular size is usually on the order of micrometers, and 1 nm is equal to 10-3 μm. It can be seen that the nanometer Chinese medicine actually pulverizes the medicine to below the molecule or atom, and the rearrangement of the atom and the change of the molecular structure are bound to produce new substances, which in turn cause the drug. Changes in biological activity and pharmacological properties. This may result in unmatched efficacy (including new effects) of the original Chinese herbal medicines, as well as new toxic side effects. If the study found that the realgar yellowing, the two cell lines HL-60 and K562 have the dual role of inducing apoptosis and necrosis, nano-realgar in addition to the original thio arsenite containing As-O bond, newly produced The thio arsenite containing As-S bond may also be the main chemical exhibiting antitumor pharmacological activity. Due to the safety hazard and uncertainty of composition and efficacy of nano-medicine, its application is limited. Secondly, the preparation equipment of nano-particles is complicated and the cost is too high. After nano-materialization, the Chinese medicine will lose the advantage of low-cost Chinese medicine and it is difficult to promote. Although the Ministry of Science and Technology has incorporated the application of nanotechnology in traditional Chinese medicine research into the “10th Five-Year Plan†in recent years, it mainly focuses on the effective parts and effective ingredients of traditional Chinese medicine.
The new type of powder - ultra-fine Chinese medicine ultra-fine Chinese medicine, also known as micro-powder traditional Chinese medicine, Chinese medicine ultra-fine particles, Chinese medicine ultra-fine powder, is a combination of modern science and technology and traditional Chinese medicine processing technology, the traditional decoction pieces into a particle size of micron The new type of traditional Chinese medicine decoction pieces are convenient to take, and only need to be brewed in boiling water at 80 ° C for a few minutes. It is characterized in that the medicinal material is pulverized to 1 to 75 μm, and is mostly at about 15 μm. In this particle size range, the cell wall is broken without changing the molecular structure, and it does not change the arrangement of the atom or molecule of the drug, so it does not cause changes in the pharmacodynamic substance of the decoction piece, and does not change the four flavors and functions of the decoction pieces. On the contrary, it greatly increases the absorption and utilization of drugs. After ultra-micro treatment, the Chinese medicine decoction pieces have finer and more uniform particle size, increased surface area and increased porosity. The drug can be better dispersed and dissolved in the solvent, increasing the contact area between the medicinal materials and the solvent. The greater the contact area of ​​the solute with the solvent before the saturation is reached, the higher the solubility. In traditional decoction, the dissolution of active ingredients is mainly released through the cell wall and cell membrane through free diffusion. The dynamics depend on the difference of concentration gradient inside and outside the cell. After breaking the cell wall of the drug, the active ingredient can be quickly and thoroughly Dissolution. There is no doubt that the composition of the homogeneous drug will be significantly improved after ultrafine pulverization. Our experiments show that ginseng saponins immersed in water such as micronized ginseng , red ginseng, American ginseng , and notoginseng are higher than traditional decoction pieces and are related to powder particle size. A large number of other domestic studies have also confirmed that Chinese herbal medicines can increase their dissolution rate and bioavailability after ultrafine pulverization, and reduce the dosage of traditional Chinese medicines. On the other hand, in its essence, ultramicro Chinese medicine is a new type of dispersing agent. The so-called powder refers to a preparation in which a single or several flavor drugs are powdered according to the prescribed processing method and preparation method, and can be classified into a powder dispersing agent and a boiling powder according to the method of administration. As a kind of traditional Chinese medicine, powder has a long history. As early as in the Warring States Period, the "Fifty-two Diseases" has a similar record. The Song Dynasty National Pharmacopoeia "Taiping Huimin and the Agent Bureau" received 1/3 of the book. It is a powder. The drugs included in the "Compendium of Materia Medica" in the Ming Dynasty are almost always marked with the end. It can be seen that the ultra-fine Chinese medicine only replaces the traditional method of “research, frustration, sputum and sieving†with the high-tech ultra-fine powder breaking technology, and the powder particle size is increased from tens and nearly 100 mesh of powder to nearly 1,000 mesh.
In summary, the ultra-fine Chinese medicine has both historical roots, conforms to the theory of traditional Chinese medicine, can be added and subtracted with the disease, is convenient to use, and can save medicines without increasing the cost of patients, although there are still many fields (such as safety and clinical dosage). Etc.) Further research is needed. Today, with increasing social pressure, increasing competition and increasingly scarce natural resources, it is still an ideal Chinese herbal medicine. (Cai Guangxian Liu Baiyan Hunan University of Traditional Chinese Medicine)
The traditional Chinese medicine decoction piece refers to a certain size of the original drug slice which is made by the process of net selection, selection and processing of Chinese medicinal materials under the guidance of the theory of traditional Chinese medicine, without any solvent extraction, concentration, granulation and Other processes. The clinical use can show the strong vitality due to the appropriate flexibility, reduction and subtraction of the drugs and drugs in the prescriptions due to time, place and people. However, traditional Chinese medicine decoction pieces have some shortcomings, such as temporary decoction before use, inconvenient to use and carry; raw materials are of different origin, quality is not good; some pieces are thick and large, the effective rate of active ingredients is low, the medicine Low utilization rate, wasted resources; some medicinal materials have poor shape and odor. Therefore, traditional Chinese medicine decoction pieces cannot be widely accepted. Therefore, the ideal modern Chinese medicine decoction pieces should conform to the requirements of TCM theory, convenient compatibility, convenient taking, controllable quality, and reasonable price. The author intends to compare the main new decoction pieces on the market, such as formula granules, nano-medicine, ultra-micro-medicine, etc. from the above aspects. Talk about personal views on the reform of the decoction.
"Scientific Chinese Medicine" is not scientifically recognized by the industry management department and is widely promoted in the market. The new Chinese medicine is a single-flavored formula granule. The formula granule is also called scientific Chinese medicine and free Chinese medicine. Zui originated in Japan, Korea and other countries. Then passed to our country. It is prepared by processing the single-flavored medicinal materials according to the physical and chemical properties of the traditional Chinese medicine, and is selected by modern industrial extraction, concentration, drying and granulation. Although it is easy to use and easy to use, it extracts all the active ingredients of single-flavored Chinese medicine in the industry. It needs to be heated during the concentration and drying process. The unstable components in the medicine may be lost. On the other hand, the pharmacological action of traditional Chinese medicine is not a single herb. The accumulation of active ingredients also includes the changes in the content of the components caused by adsorption, precipitation, solubilization, and solubilization during the decoction process, as well as the new substances produced by hydrolysis, oxidation and reduction between the components. Therefore, whether the simple mixing of the single-flavored Chinese medicine ingredients after extraction is equivalent to the traditional boiling is not certain. Studies have shown that Shengmai Sanhe Decoction is more effective than myocardial ischemia, and the combination of some drugs has attenuated and synergistic effects. It is well known that aconitine in aconite is not obvious when it is used alone, and it is easy to cause ectopic rhythm. Dried ginger and licorice have no cardiotonic effect. Sini decoction composed of aconite has a significant cardiotonic effect and the ectopic rhythm effect is greatly reduced. The mixture of single-flavored drug extracts can not reduce its toxicity. Because of this, Zui, who advocated the formulation of granules in Japan, Korea, Taiwan, etc., now uses less single-flavored granules, and the compound granules extracted after decocting are the main ones. Formula granules also have shortcomings such as the influence of the addition of excipients on the taste, easy to regain moisture and agglomeration.
Nano-Chinese medicine is difficult to promote Nano-Chinese medicine refers to the active ingredients, effective parts, original medicines and their compound preparations of traditional Chinese medicine manufactured by using nanotechnology in the range of 100nm particle size. Nano-medicine decoction pieces are only a part of them. The molecular size is usually on the order of micrometers, and 1 nm is equal to 10-3 μm. It can be seen that the nanometer Chinese medicine actually pulverizes the medicine to below the molecule or atom, and the rearrangement of the atom and the change of the molecular structure are bound to produce new substances, which in turn cause the drug. Changes in biological activity and pharmacological properties. This may result in unmatched efficacy (including new effects) of the original Chinese herbal medicines, as well as new toxic side effects. If the study found that the realgar yellowing, the two cell lines HL-60 and K562 have the dual role of inducing apoptosis and necrosis, nano-realgar in addition to the original thio arsenite containing As-O bond, newly produced The thio arsenite containing As-S bond may also be the main chemical exhibiting antitumor pharmacological activity. Due to the safety hazard and uncertainty of composition and efficacy of nano-medicine, its application is limited. Secondly, the preparation equipment of nano-particles is complicated and the cost is too high. After nano-materialization, the Chinese medicine will lose the advantage of low-cost Chinese medicine and it is difficult to promote. Although the Ministry of Science and Technology has incorporated the application of nanotechnology in traditional Chinese medicine research into the “10th Five-Year Plan†in recent years, it mainly focuses on the effective parts and effective ingredients of traditional Chinese medicine.
The new type of powder - ultra-fine Chinese medicine ultra-fine Chinese medicine, also known as micro-powder traditional Chinese medicine, Chinese medicine ultra-fine particles, Chinese medicine ultra-fine powder, is a combination of modern science and technology and traditional Chinese medicine processing technology, the traditional decoction pieces into a particle size of micron The new type of traditional Chinese medicine decoction pieces are convenient to take, and only need to be brewed in boiling water at 80 ° C for a few minutes. It is characterized in that the medicinal material is pulverized to 1 to 75 μm, and is mostly at about 15 μm. In this particle size range, the cell wall is broken without changing the molecular structure, and it does not change the arrangement of the atom or molecule of the drug, so it does not cause changes in the pharmacodynamic substance of the decoction piece, and does not change the four flavors and functions of the decoction pieces. On the contrary, it greatly increases the absorption and utilization of drugs. After ultra-micro treatment, the Chinese medicine decoction pieces have finer and more uniform particle size, increased surface area and increased porosity. The drug can be better dispersed and dissolved in the solvent, increasing the contact area between the medicinal materials and the solvent. The greater the contact area of ​​the solute with the solvent before the saturation is reached, the higher the solubility. In traditional decoction, the dissolution of active ingredients is mainly released through the cell wall and cell membrane through free diffusion. The dynamics depend on the difference of concentration gradient inside and outside the cell. After breaking the cell wall of the drug, the active ingredient can be quickly and thoroughly Dissolution. There is no doubt that the composition of the homogeneous drug will be significantly improved after ultrafine pulverization. Our experiments show that ginseng saponins immersed in water such as micronized ginseng , red ginseng, American ginseng , and notoginseng are higher than traditional decoction pieces and are related to powder particle size. A large number of other domestic studies have also confirmed that Chinese herbal medicines can increase their dissolution rate and bioavailability after ultrafine pulverization, and reduce the dosage of traditional Chinese medicines. On the other hand, in its essence, ultramicro Chinese medicine is a new type of dispersing agent. The so-called powder refers to a preparation in which a single or several flavor drugs are powdered according to the prescribed processing method and preparation method, and can be classified into a powder dispersing agent and a boiling powder according to the method of administration. As a kind of traditional Chinese medicine, powder has a long history. As early as in the Warring States Period, the "Fifty-two Diseases" has a similar record. The Song Dynasty National Pharmacopoeia "Taiping Huimin and the Agent Bureau" received 1/3 of the book. It is a powder. The drugs included in the "Compendium of Materia Medica" in the Ming Dynasty are almost always marked with the end. It can be seen that the ultra-fine Chinese medicine only replaces the traditional method of “research, frustration, sputum and sieving†with the high-tech ultra-fine powder breaking technology, and the powder particle size is increased from tens and nearly 100 mesh of powder to nearly 1,000 mesh.
In summary, the ultra-fine Chinese medicine has both historical roots, conforms to the theory of traditional Chinese medicine, can be added and subtracted with the disease, is convenient to use, and can save medicines without increasing the cost of patients, although there are still many fields (such as safety and clinical dosage). Etc.) Further research is needed. Today, with increasing social pressure, increasing competition and increasingly scarce natural resources, it is still an ideal Chinese herbal medicine. (Cai Guangxian Liu Baiyan Hunan University of Traditional Chinese Medicine)
This unit is specially designed for ultrafine powdery materials, with unique structure, accurate weighing and stable reliability; It is one of the most technical weigher machine for powder. Can pack many kinds of powdery material and powdery mixer, such as medical raw material, flour, milk powder and so on. The machine contains double auger weigher(one big weigher and one small weigher): All parts are of Omni seal, prevent powder lost from the machine. Its weighing control system is controlled centrally by PLC and is designed according to IP54 (dustproof and waterproof) requirement; This unit consists of fully automatic weighing machine (including bag clamp mechanism), conveyor, bag sewing machine and automatic control cabinet; The mechanical section is fed by horizontal double auger with independent metering and deducting mechanism, fast metering speed and high accuracy; Options multiple devices available for free selection (conveyor, bag sewing machine, sealing machine, elevator, air pump, dust collector, metal detector, over-allowance checker... It can be tailor-made according to the customer's need and site.
Weighing range
5-10kg
Weighing accuracy
±0.1%-0.5%
Weighing rate
120-400 bags/h
Power/current
5kW/10A
Air supply pressure
0.36MPa
Metering mode
Suspension sensor
Frequency/voltage
50Hz/60Hz/220V/380V
Power supply mode
3-phase 5-wire system
External dimensions (L*W*H)
4000*2000*3000 (mm)
Unit weight
800 kg
Powder Bagging Scale System
Powder Bagging Scale System,Packaging Systems For Powder,Powder Scale,Bagging Packing Scale System
SHIJIAZHUANG SYNMEC INTERNATIONAL TRADING LIMITED , https://www.seedgraincleaner.com